07567349 is referenced by 30 patents and cites 341 patents.

Speckle, a factor reducing image quality in optical coherence tomography (“OCT”), can limit the ability to identify cellular structures that are important for the diagnosis of a variety of diseases. Exemplary embodiments of the present invention can facilitate an implementation of an angular compounding, angular compounding by path length encoding (“ACPE”) for reducing speckle in OCT images. By averaging images obtained at different incident angles, with each image encoded by path length, ACPE maintains high-speed image acquisition and implements minimal modifications to OCT probe optics. ACPE images obtained from tissue phantoms and human skin in vivo demonstrate a qualitative improvement over traditional OCT and an increased signal-to-noise ratio (“SNR”). Accordingly, exemplary embodiments of an apparatus probe catheter and method can be provided for irradiating a sample. In particular, an interferometer may forward forwarding an electromagnetic radiation. In addition, a sample arm may receive the electromagnetic radiation, and can include an arrangement which facilitates a production of at least two radiations from the electromagnetic radiation so as to irradiate the sample. Such exemplary arrangement can be configured to delay a first radiation of the at least two radiations with respect to a second radiation of the at least two radiations.

Title
Speckle reduction in optical coherence tomography by path length encoded angular compounding
Application Number
10/551735
Publication Number
7567349 (B2)
Application Date
March 31, 2004
Publication Date
July 28, 2009
Inventor
Brett Eugene Bouma
Quincy
MA, US
Nicusor Iftimia
Quincy
MA, US
Guillermo J Tearney
Cambridge
MA, US
Agent
Dorsey & Whitney
Assignee
The General Hospital Corporation
MA, US
IPC
G01B 9/02
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