07547684 is referenced by 101 patents and cites 135 patents.

The present invention provides 5′-modified bicyclic nucleoside analogs and oligomeric compounds comprising at least one of these nucleoside analogs. In preferred embodiments the nucleoside analogs have either (R) or (S)-chirality at the 5′-carbon. These bicyclic nucleoside analogs are useful for enhancing properties of oligomeric compounds including for example enhanced nuclease resistance.

Title
5′-modified bicyclic nucleic acid analogs
Application Number
11/747057
Publication Number
7547684 (B2)
Application Date
May 10, 2007
Publication Date
June 16, 2009
Inventor
Balkrishen Bhat
Carlsbad
CA, US
Eric E Swayze
Carlsbad
CA, US
Punit P Seth
San Marcos
CA, US
Agent
Jones Day
Assignee
Isis Pharmaceuticals
CA, US
IPC
A61K 31/70
A01N 43/04
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