07544933 is referenced by 44 patents and cites 24 patents.

A desorption atmospheric pressure chemical ionization (DAPCI) system delivers a primary ion beam composed of an inert, high velocity gas and solvent ions to a surface to effect desorption and ionization of both volatile and non-volatile species present on surfaces. A electrode having a tapered tip is connected to a high voltage power supply. The tapered tip projects outward from a capillary carrying a high-speed flow of gas. A vapor of a solvent is mixed into the annular gas flow surrounding the needle. The gaseous solvent vapor is ionized in close proximity to the tapered tip by virtue of the high voltage applied to the electrode. The high-speed flow of gas and solvent vapor ions extending outward from the capillary is directed toward a substrate on which an analyte of interest may have been deposited. The solvent vapor ions can blanket the surface of the analyte causing a static charge build up that facilitates ion desorption and additionally can provide positive ion adducts of the analyte freed from the substrate surface that can be directed toward an atmospheric intake of a mass spectrometer or other instrument capable of studying the analyte.

Title
Method and system for desorption atmospheric pressure chemical ionization
Application Number
11/653569
Publication Number
7544933 (B2)
Application Date
January 16, 2007
Publication Date
June 9, 2009
Inventor
Ismael Cotte Rodriguez
West Lafayette
IN, US
Justin M Wiseman
Avon
IN, US
Zoltán Takáts
Budapest
HU
Bogdan Gologan
Hoboken
NJ, US
Robert G Cooks
West Lafayette
IN, US
Agent
Lawson & Weitzen
Sonia K Guterman
Assignee
Purdue Research Foundation
IN, US
IPC
H01J 49/00
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