07534866 is referenced by 72 patents and cites 13 patents.

The present invention concerns methods and compositions for making and using bioactive assemblies of defined compositions, which may have multiple functionalities and/or binding specificities. In particular embodiments, the bioactive assembly is formed using dock-and-lock (DNL) methodology, which takes advantage of the specific binding interaction between dimerization and docking domains (DDD) and anchoring domains (AD) to form the assembly. In various embodiments, one or more effectors may be attached to a DDD or AD sequence. Complementary AD or DDD sequences may be attached to an adaptor module that forms the core of the bioactive assembly, allowing formation of the assembly through the specific DDD/AD binding interactions. Such assemblies may be attached to a wide variety of effector moieties for treatment, detection and/or diagnosis of a disease, pathogen infection or other medical or veterinary condition.

Title
Methods and compositions for generating bioactive assemblies of increased complexity and uses
Application Number
11/478021
Publication Number
7534866 (B2)
Application Date
June 29, 2006
Publication Date
May 19, 2009
Inventor
Edmund A Rossi
Nutley
NJ, US
William J McBride
Boonton
NJ, US
David M Goldenberg
Mendham
NJ, US
Chien Hsing Chang
Downingtown
PA, US
Agent
Richard A Nakashima
Assignee
IBC Pharmaceuticals
NJ, US
IPC
G01N 33/53
C12Q 1/68
C07K 16/46
A61K 51/00
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