07527787 is referenced by 71 patents and cites 9 patents.

The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Preferred embodiments concern hexameric stably tethered structures comprising one or more IgG antibody fragments and which may be monospecific or bispecific. The disclosed methods and compositions provide a facile and general way to obtain stably tethered structures of virtually any functionality and/or binding specificity. The stably tethered structures may be administered to subjects for diagnostic and/or therapeutic use, for example for treatment of cancer or autoimmune disease. The stably tethered structures may bind to and/or be conjugated to a variety of known effectors, such as drugs, enzymes, radionuclides, therapeutic agents and/or diagnostic agents.

Title
Multivalent immunoglobulin-based bioactive assemblies
Application Number
11/633729
Publication Number
7527787 (B2)
Application Date
December 5, 2006
Publication Date
May 5, 2009
Inventor
Edmund A Rossi
Nutley
NJ, US
David M Goldenberg
Mendham
NJ, US
Chien Hsing Chang
Downingtown
PA, US
Agent
Richard A Nakashima
Assignee
IBC Pharmaceuticals
NJ, US
IPC
A61K 38/16
C07K 16/30
C07K 16/46
C07K 16/28
C07K 1/32
View Original Source