07520866 is referenced by 12 patents and cites 178 patents.

Topical exposure of nitric oxide gas to wounds such as chronic non-healing wounds may be beneficial in promoting healing of the wound and in preparing the wound bed for further treatment and recovery. Nitric oxide gas may be used, for example, to reduce the microbial infection and burden on these wounds, manage exudate secretion by reducing inflammation, upregulate expression of endogenous collagenase to locally debride the wound, and regulate the formation of collagen. High concentration of nitric oxide ranging from about 160 to 400 ppm may be used without inducing toxicity in the healthy cells around a wound site. Additionally, exposure to the high concentration for a first treatment period reduces the microbial burden and inflammation at the wound site and increase collagenase expression to debride necrotic tissue at the wound site. After a first treatment period with high concentration of nitric oxide, a second treatment period at a lower concentration of nitric oxide preferably ranging from about 5-20 ppm may to provided to restore the balance of nitric oxide and induce collagen expression to aid in the closure of the wound.

Device and method for treatment of wounds with nitric oxide
Application Number
Publication Number
7520866 (B2)
Application Date
July 13, 2006
Publication Date
April 21, 2009
Chris C Miller
North Vancouver
Alex Stenzler
Long Beach
Sidley Austin
Pulmonox Technologies Corporation
Sensormedics Corporation
A01N 59/02
A61M 1/00
A61M 37/00
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