07510849 is referenced by 252 patents and cites 99 patents.

This invention relates to a method of diagnosing or treating a biological subject, such as a person or animal, comprising the steps of subjecting at least a microsample of the subject's tissue to a physiological perturbation and measuring the response of the microsample to the perturbation using optical coherence tomography (OCT). In an exemplary embodiment, the concentration of glucose in the microsample is perturbed, as by providing the subject with a high glucose drink, and subsequently monitoring at a high sample rate in a microsample by OCT. Pathology, such as diabetes, can be diagnosed by deviation of the concentration vs. time response over several cells (micro-oscillation) from the micro-oscillation in the cells of a healthy subject. Other applications include diagnosing or treating de-hydration and diseases that cause changes in the osmolyte concentrations and thus the osmotic pressure in the cells in tissue.

Title
OCT based method for diagnosis and therapy
Application Number
11/40388
Publication Number
7510849 (B2)
Application Date
January 21, 2005
Publication Date
March 31, 2009
Inventor
Walter Jeffrey Shakespeare
Macungie
PA, US
Matthew J Schurman
Somerset
NJ, US
Agent
Nutter McClennen & Fish
Charlton Shen
Thomas J Engellenner
Assignee
GlucoLight Corporation
PA, US
IPC
C12Q 1/54
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