07473421 is referenced by 4 patents and cites 48 patents.

The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.

Title
Humanized anti-CCR2 antibodies and methods of use therefor
Application Number
10/766773
Publication Number
7473421 (B2)
Application Date
January 27, 2004
Publication Date
January 6, 2009
Inventor
Theresa O Keefe
Waltham
MA, US
Siobhan H O Brien
London
GB
S Tarran Jones
Radlett
GB
Walter Newman
Boston
MA, US
Christopher Horvath
Taunton
MA, US
Gregory J LaRosa
Newton
MA, US
Agent
Lowrie Lando & Anastasi
Assignee
Millennium Pharmaceuticals
MA, US
IPC
A61K 39/02
C07K 16/00
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