07469160 is referenced by 27 patents and cites 364 patents.

The invention provides methods of focusing an instrument for the acquisition of optical data from a tissue sample. Methods of the invention allow rapid focusing in the context of a diagnostic procedure in which rapid data acquisition is desirable. For example, inventive methods allow a user to focus an optical instrument quickly enough to obtain data within an optimal window of time following application of a chemical agent to the tissue. In one embodiment, a user focuses an optical instrument by aligning laser spots projected onto a tissue sample within rings that are superimposed at predetermined locations within the user's visual field. Preferred methods of the invention further comprise automatic validation to detect whether the spots are sufficiently well-aligned.

Title
Methods and apparatus for evaluating image focus
Application Number
10/419181
Publication Number
7469160 (B2)
Application Date
April 18, 2003
Publication Date
December 23, 2008
Inventor
Charles C Abele
Newton, 02461
MA, US
Richard M Morrell
Upton, 01568
MA, US
Karen M Twietmeyer
Tucson, 85718
AZ, US
Chunsheng Jiang
Reading, 01867
MA, US
Perry S Banks
Hollis, 03049
NH, US
Agent
Fish & Richardson P C
IPC
A61B 6/00
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