07427394 is referenced by 45 patents and cites 10 patents.

Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings. A system for preparing and screening polymers in parallel using semi-automated robotic fluid delivery systems is also provided.

Title
Biodegradable poly(β-amino esters) and uses thereof
Application Number
10/446444
Publication Number
7427394 (B2)
Application Date
May 28, 2003
Publication Date
September 23, 2008
Inventor
Robert S Langer
Newton
MA, US
Akin Akinc
Newton
MA, US
David M Lynn
Middleton
WI, US
Daniel G Anderson
Framingham
MA, US
Agent
C Hunter Baker
Choate Hall & Stewart
Assignee
The United States of Americas represented by the Secretary of the Army
DC, US
Massachusetts Institute of Technology
MA, US
IPC
C07C 327/00
C08G 63/44
C08G 69/44
A61K 31/765
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