07419835 is referenced by 17 patents and cites 5 patents.

A method for screening of compounds for binding differentiation at various drug target binding sites is used with a device measuring the enthalpy of reaction for the binding. The method includes merging test ligand with target compound and merging test ligand with target compound in the presence of at least one blocking agent. A first heat of reaction is detected for the merged test ligand and target compound solution and a second heat of reaction is detected for the merged test ligand and target compound solution in the presence of a blocking agent. The two heats of reaction are compared to determine whether a reaction has occurred.

Title
Screening for ligand binding at specific target sites
Application Number
10/719457
Publication Number
7419835 (B2)
Application Date
November 21, 2003
Publication Date
September 2, 2008
Inventor
Rodney Turner
San Francisco
CA, US
Richard H Bruce
Los Altos
CA, US
Francisco E Torres
San Jose
CA, US
Agent
Fay Sharpe
Assignee
Palo Alto Research Center Incorporated
CA, US
IPC
G01N 25/20
G01N 35/00
G01K 17/20
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