07419686 is referenced by 60 patents and cites 221 patents.

The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is analgesically effective when the combination is administered orally, but which is aversive in a physically dependent subject. Preferably, the amount of opioid antagonist included in the combination product provides at least a mildly negative, “aversive” experience in physically dependent addicts (e.g., precipitated abstinence syndrome).

Title
Opioid agonist/antagonist combinations
Application Number
11/645401
Publication Number
7419686 (B2)
Application Date
December 26, 2006
Publication Date
September 2, 2008
Inventor
Robert D Colucci
Newtown
CT, US
Robert F Kaiko
Weston
CT, US
Agent
Davidson Davidson & Kappel
Assignee
Purdue Pharma
CT, US
IPC
A61K 9/54
A61K 9/52
A61K 9/48
A61K 9/26
A61K 9/22
A61K 9/20
A61K 9/14
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