Method for high-throughput screening assay sample preparation and analysis United States Patent 07416897

07416897 is referenced by 9 patents and cites 6 patents.

A method is disclosed for high-throughput screening assay sample preparation and testing for the identification of binding between drug targets and library compounds, for use with a calorimetric device measuring the enthalpy of reaction for the binding. The method includes mixing a library compound with a specified solvent and mixing a target compound solution with a second specified solvent on a calorimetric device. The library compound/solvent is merged with the target compound/solvent solution and the library compound/solvent solution is also merged with a third solvent solution on the calorimetric device. The heats of reaction are detected for both merged solutions and are compared.

Title
Method for high-throughput screening assay sample preparation and analysis
Application Number
10/719961
Publication Number
7416897 (B2)
Application Date
November 21, 2003
Publication Date
August 26, 2008
Inventor
Eric Peeters
Fremont
CA, US
Alan G Bell
Palo Alto
CA, US
Francisco E Torres
San Jose
CA, US
Richard H Bruce
Los Altos
CA, US
Agent
Fay Sharpe
Assignee
Palo Alto Research Center Incorporated
CA, US
IPC
G01N 25/20
G01N 35/00
G01K 17/20
G01K 17/00
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Citations: 9

  1. Dirk De Bruyker, Michal V Wolkin: Vanadium oxide thermal microprobes. Palo Alto Research Center Incorporated, Fay Sharpe, March 6, 2012: US08130072 (8 worldwide citation)
  2. Richard H Bruce, Steven Rosenberg: Method for multiple target assay for drug discovery. Palo Alto Research Center Incorporated, Leading Edge Law Group, James T Beran, April 21, 2009: US07521253 (7 worldwide citation)
  3. Alan Bell, Richard H Bruce, Eric Peeters, Michal V Wolkin, Dirk De Bruyker: Thermal sensing with bridge circuitry. Palo Alto Research Center Incorporated, Mark W Hrozenchik, Leading Edge Law Group, November 16, 2010: US07833800 (5 worldwide citation)
  4. Alan G Bell, Richard H Bruce, Scott A Elrod, Eric Peeters, Francisco E Torres: Method for a nanocalorimeter for detecting chemical reactions. Palo Alto Research Center Incorporated, Leading Edge Law Group, Mark W Hrozenchik, June 1, 2010: US07727768 (4 worldwide citation)
  5. Michael I Recht, Francisco E Torres, Richard H Bruce, Alan G Bell: Ranking fragment types with calorimetry. Palo Alto Research Center Incorporated, Leading Edge Law Group, James T Beran, December 15, 2009: US07632008 (4 worldwide citation)
  6. Alan Bell, Richard H Bruce, Eric Peeters: Thermal sensing device. Palo Alto Research Center Incorporated, Leading Edge Law Group, Mark W Hrozenchik, July 13, 2010: US07754492 (3 worldwide citation)
  7. Dirk De Bruyker, Francisco E Torres, Michal V Wolkin, Gregory B Anderson, Eugene M Chow: Nanocalorimeter based on thermal probes. Palo Alto Research Center Incorporated, Fay Sharpe, March 12, 2013: US08393785 (1 worldwide citation)
  8. Martin Broga, Phillip Price, Stephen Smith: Automatic isothermal titration microcalorimeter apparatus and method of use. MALVERN INSTRUMENTS INCORPORATED, Morrison & Foerster, August 2, 2016: US09404876
  9. Martin Broga, Phillip Price, Stephen Smith: Automatic isothermal titration microcalorimeter apparatus and method of use. Malvern Panalytical, Morrison & Foerster, July 31, 2018: US10036715

References: 6

  1. Katarina Verhaegen: Device and a method for thermal sensing. Imec VZW, Knobbe Martens Olson & Bear, April 8, 2003: US06545334 (20 worldwide citation)
  2. Katarina Verhaegen: Device and a method for thermal sensing. IMEC vzw, Knobbe Martens Olson & Bear, April 30, 2002: US06380605 (27 worldwide citation)
  3. Frederick F Becker, Peter Gascoyne, Xiaobo Wang, Jody Valentine Vykoukal, Giovanni De Gasperis: Method and apparatus for programmable fluidic processing. Board of Regents The University of Texas System, Fulbright & Jaworski, September 25, 2001: US06294063 (262 worldwide citation)
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  5. February, 2004: US2004/0038227
  6. April, 2005: US2005/0076943