07402410 cites 44 patents.

The present invention relates to isolated nucleic acids encoding humanized immunoglobulins having binding specificity for α4β7 integrin, isolated nucleic acids encoding a humanized immunoglobulin heavy chain and isolated nucleic acids encoding a humanized light chain having binding specificity for α4β7 integrin. The invention also relates to expression vectors and host cells comprising a nucleotide sequence which encodes a humanized immunoglobulin or antigen-binding fragment thereof having binding specificity for α4β7. The invention further relates to methods of preparing a humanized immunoglobulin, humanized immunoglobulin heavy chain and humanized immunoglobulin light chain that has binding specificity for α4β7 integrin.

Title
Humanized immunoglobulin reactive with α4β7 integrin
Application Number
11/511164
Publication Number
7402410 (B2)
Application Date
August 28, 2006
Publication Date
July 22, 2008
Inventor
Mary M Bendig
London
GB
José Saldanha
Middlesex
GB
Walter Newman
Boston
MA, US
S Tarran Jones
Radlett
GB
Douglas J Ringler
Revere
MA, US
Paul D Ponath
Boston
MA, US
Agent
Hamilton Brook Smith & Reynolds P C
Assignee
Millennium Pharmaceuticals
MA, US
IPC
C12P 21/04
C12N 5/10
C12N 15/63
C12N 15/13
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