07399845 is referenced by 184 patents and cites 143 patents.

The present invention provides 6-modified bicyclic nucleoside analogs and oligomeric compounds comprising these nucleoside analogs. In preferred embodiments the nucleoside analogs have either (R) or (S)-chirality at the 6-position. These bicyclicnucleoside analogs are useful for enhancing properties of oligomeric compounds including nuclease resistance.

Title
6-modified bicyclic nucleic acid analogs
Application Number
11/627964
Publication Number
7399845 (B2)
Application Date
January 27, 2007
Publication Date
July 15, 2008
Inventor
Eric E Swayze
Carlsbad
CA, US
Punit P Seth
San Marcos
CA, US
Agent
Jones Day
Assignee
Isis Pharmaceuticals
CA, US
IPC
A61K 31/70
A01N 43/04
C07H 21/00
C07H 19/00
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