07381418 is referenced by 35 patents and cites 38 patents.

An implantable or insertable medical device which comprises (a) a therapeutic agent and (b) a polymeric release region that controls the release of the therapeutic agent upon administration to a patient. The polymeric release region comprises a radiation-crosslinked polymer, and the polymeric release region is crosslinked with a radiation dose of at least 10,000 rads. The radiation-crosslinked polymer can be, for example, a radiation-crosslinked methylene-containing polymer. The polymeric release region can be, for example, (a) a carrier region that comprises the therapeutic agent or (b) a barrier region that is disposed over a therapeutic-agent-containing region that comprises the therapeutic agent. The present invention is further directed to methods of forming such medical devices, methods of releasing a therapeutic agent within a patient using such medical devices, and methods of modulating the release of a therapeutic agent from such medical devices.

Title
Implantable or insertable medical devices containing radiation-crosslinked polymer for controlled delivery of a therapeutic agent
Application Number
11/825383
Publication Number
7381418 (B2)
Application Date
July 5, 2007
Publication Date
June 3, 2008
Inventor
Robert E Richard
Wrentham
MA, US
Agent
David B Bonham Esq
Keum J Park Esq
Mayer & Williams PC
Assignee
Boston Scientific Scimed
MN, US
IPC
A61K 47/30
A61F 2/00
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