07335897 is referenced by 62 patents and cites 15 patents.

A new method and system for desorption ionization is described and applied to the ionization of various compounds, including peptides and proteins present on metal, polymer, and mineral surfaces. Desorption electrospray ionization (DESI) is carried out by directing charged droplets and/or ions of a liquid onto the surface to be analyzed. The impact of the charged particles on the surface produces gaseous ions of material originally present on the surface. The resulting mass spectra are similar to normal ESI mass spectra in that they show mainly singly or multiply charged molecular ions of the analytes. The DESI phenomenon was observed both in the case of conductive and insulator surfaces and for compounds ranging from nonpolar small molecules such as lycopene, the alkaloid coniceine, and small drugs, through polar compounds such as peptides and proteins. Changes in the solution that is sprayed can be used to selectively ionize particular compounds, including those in biological matrices. In vivo analysis is demonstrated.

Title
Method and system for desorption electrospray ionization
Application Number
11/90455
Publication Number
7335897 (B2)
Application Date
March 25, 2005
Publication Date
February 26, 2008
Inventor
Robert Graham Cooks
West Lafayette
IN, US
Justin Michael Wiseman
Indianapolis
IN, US
Bogdan Gologan
Lafayette
IN, US
Zoltán Takáts
Budapest
HU
Agent
Adam M Schoen
Sonia K Guterman
Lawson & Weitzen
Assignee
Purdue Research Foundation
IN, US
IPC
H01J 49/10
H01J 27/00
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