07321828 is referenced by 130 patents and cites 212 patents.

Interative, preferably computer based iterative processes for generating synthetic compounds with desired physical, chemical and/or bioactive properties, i.e., active compounds, are provided. During iterations of the processes, a target nucleic acid sequence is provided or selected, and a library of candidate nucleobase sequences is generated in silico according to defined criteria. A “virtual” oligonucleotide chemistry is chosen and a library of virtual oligonucleotide compounds having the selected nucleobase sequences is generated. These virtual compounds are reviewed and compounds predicted to have particular properties are selected. The selected compounds are robotically synthesized and are preferably robotically assayed for a desired physical, chemical or biological activity. Active compounds are thus generated and, at the same time, preferred sequences and regions of the target nucleic acid that are amenable to oligonucleotide or sequence-based modulation are identified.

Title
System of components for preparing oligonucleotides
Application Number
9/67638
Publication Number
7321828 (B2)
Application Date
April 28, 1998
Publication Date
January 22, 2008
Inventor
Timothy A Vickers
Oceanside
CA, US
Alexander H Borchers
Encinitas
CA, US
Jacqueline R Wyatt
Encinitas
CA, US
Cara Ohashi
San Francisco
CA, US
Douglas G Brooks
San Marcos
CA, US
Henri M Sasmor
Oceanside
CA, US
Susan M Freier
San Diego
CA, US
John McNeil
La Jolla
CA, US
Brenda F Baker
Carlsbad
CA, US
Lex M Cowsert
Carlsbad
CA, US
Assignee
Isis Pharmaceuticals
CA, US
IPC
C12Q 1/68
G06F 19/00
C12P 19/34
View Original Source