07320675 is referenced by 26 patents and cites 254 patents.

A drug delivery system detects a cardiac condition indicative of a need for increasing a cardiac metabolic level and, in response, releases a drug into tissue or blood to shift a source of metabolically synthesized energy fueling cardiac contraction from fatty acid to glucose. One example of such a system includes an implantable device detecting an ischemia and a transdermal drug delivery device delivering a drug when an ischemic condition is detected. Another example of such a system includes one or more implantable devices detecting a predefined change in cardiac metabolic level and delivering a drug when the change is detected. Such systems are applied to treat, for example, patients suffering ischemia and/or heart failure and patients having suffered myocardial infarction.

Title
Method and apparatus for modulating cellular metabolism during post-ischemia or heart failure
Application Number
10/645823
Publication Number
7320675 (B2)
Application Date
August 21, 2003
Publication Date
January 22, 2008
Inventor
Allan Shuros
St. Paul
MN, US
Rodney W Salo
Fridley
MN, US
Jeffrey Ross
Roseville
MN, US
Helen L Reeve
St. Paul
MN, US
Julio C Spinelli
Shoreview
MN, US
Joseph M Pastore
Minneapolis
MN, US
Agent
Schwegman Lundberg & Woessner P A
Assignee
Cardiac Pacemakers
MN, US
IPC
A61M 31/00
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