07303814 is referenced by 43 patents and cites 61 patents.

The present invention is directed to a stabilized bioactive hydrogel matrix coating for substrates, such as medical devices. The invention provides a coated substrate comprising a substrate having a surface, and a bioactive hydrogel matrix layer overlying the surface of the medical device, the hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component, the first and second high molecular weight components each being selected from the group consisting of polyglycans and polypeptides, wherein at least one of the first and second high molecular weight components is immobilized (e.g., by covalent cross-linking) to the surface of the substrate.

Title
Immobilized bioactive hydrogel matrices as surface coatings
Application Number
10/372757
Publication Number
7303814 (B2)
Application Date
February 21, 2003
Publication Date
December 4, 2007
Inventor
Ronald Stewart Hill
Greenville
NC, US
Richard Chris Klann
Washington
NC, US
Francis V Lamberti
Greenville
NC, US
Agent
Alston & Bird
Assignee
Encelle
NC, US
IPC
B32B 19/00
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