07279146 is referenced by 140 patents and cites 90 patents.

High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to vary the solution condition in the chambers, thereby simultaneously providing a large number of crystallization environments. Control over changed solution conditions may result from a variety of techniques, including but not limited to metering volumes of crystallizing agent into the chamber by volume exclusion, by entrapment of volumes of crystallizing agent determined by the dimensions of the microfabricated structure, or by cross-channel injection of sample and crystallizing agent into an array of junctions defined by intersecting orthogonal flow channels.

Title
Crystal growth devices and systems, and methods for using same
Application Number
10/827917
Publication Number
7279146 (B2)
Application Date
April 19, 2004
Publication Date
October 9, 2007
Inventor
Joseph W Barco
South San Francisco
CA, US
Geoffrey Facer
San Francisco
CA, US
Hany Ramez Nassef
San Mateo
CA, US
Agent
Townsend and Townsend and Crew
Assignee
Fluidigm Corporation
CA, US
IPC
C30B 29/54
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