07253178 is referenced by 3 patents and cites 5 patents.

The present invention provides a novel carboxylic acid derivative, a salt thereof or a hydrate of them which is useful as an insulin sensitizer, and a medicament comprising the derivative as the effective ingredient. More specifically, it provides a carboxylic acid compound represented by the formula (I), a salt thereof or a hydrate of them. In the formula, Ar represents a 6- to 14-membered aromatic ring group which may have at least one substituent; R1, R2, R3, R4, R5, R6, R7 and R8 are the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a C1-6 alkyl group or a C1-6 alkoxy group; X represents an oxygen atom or a methylene group; Y represents a group represented by the formula (II) or (III): (wherein Z represents a group represented by the formula (IV): (wherein R9, R10, R11 and R12 are the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a C1-6 alkyl group or a C1-6 alkoxy group)); m is 0 or 1; and n is 0 or 1.

Title
Carboxylic acids
Application Number
10/469173
Publication Number
7253178 (B2)
Application Date
March 27, 2002
Publication Date
August 7, 2007
Inventor
Taro Hihara
Ibaraki
JP
Sadakazu Miyashita
Ibaraki
JP
Takashi Inoue
Ibaraki
JP
Kazuto Yamazaki
Ibaraki
JP
Hideki Yoshitomi
Ibaraki
JP
Shunji Kasai
Ibaraki
JP
Eita Emori
Ibaraki
JP
Fumiyoshi Matsuura
Ibaraki
JP
Richard Clark
Ibaraki
JP
Masanobu Shinoda
Ibaraki
JP
Hitoshi Harada
Ibaraki
JP
Agent
Birch Stewart Kolasch & Birch
Assignee
Eisai
JP
IPC
C07D 211/70
C07D 211/72
A61K 31/44
A61K 31/435
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