07227028 is referenced by 34 patents and cites 17 patents.

Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

Title
Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
Application Number
11/26491
Publication Number
7227028 (B2)
Application Date
December 30, 2004
Publication Date
June 5, 2007
Inventor
Seema Bhat
Santa Clara
CA, US
Ge Peng
Mountain View
CA, US
Maria Ludwikow
Cupertino
CA, US
Thu Phan
Fremont
CA, US
Fenmei Yao
Mountain View
CA, US
Suresh K Manthati
Cupertino
CA, US
Stephen P Raillard
Mountain View
CA, US
Randall A Scheuerman
Santa Clara
CA, US
Xuedong Dai
San Jose
CA, US
Mark A Gallop
Los Altos
CA, US
Agent
Dorsey & Whitney
Assignee
XenoPort
CA, US
IPC
C07D 207/46
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