07226785 is referenced by 77 patents and cites 16 patents.

Presented are methods and compositions for targeted chromosomal genomic alterations using modified single-stranded oligonucleotides of the invention have at least one modified nuclease-resistant terminal region comprising phosphorothioate linkages, LNA analogs or 2′-O-Me base analogs.

Title
Targeted chromosomal genomic alterations with modified single stranded oligonucleotides
Application Number
10/261185
Publication Number
7226785 (B2)
Application Date
September 27, 2002
Publication Date
June 5, 2007
Inventor
Michael C Rice
Newtown
PA, US
Howard B Gamper
Philadelphia
PA, US
Eric B Kmiec
Landenberg
PA, US
Agent
McCarter & English
Assignee
University of Delaware
DE, US
IPC
C12N 15/00
View Original Source