07226615 is referenced by 15 patents and cites 63 patents.

Liquid, injectable, aqueous solutions are transformed in situ to an expandable foam-like, space filling, and adherent biomaterial. Preferably, the foam-like biomaterial is the reaction product of a two-part liquid system to achieve the in situ formation thereof. The liquid system is generally comprised of a protein solution and a cross linker solution which may either be premixed and then applied to a site in need of the biomaterial, or simultaneously mixed and delivered through an in-line mixing/dispensing tip directly to the site. In especially preferred embodiments, an expandable foam-like biomaterial includes the reaction product of human or animal-derived protein material and a di- or polyaldehyde in the presence of a bicarbonate and an acidic titrant amounts sufficient to impart a cellular foam structure to the material.

Title
Expandable foam-like biomaterials and methods
Application Number
9/986124
Publication Number
7226615 (B2)
Application Date
November 7, 2001
Publication Date
June 5, 2007
Inventor
Kirby S Black
Achworth
GA, US
Ana T Bird
Achworth
GA, US
K Ümit Yüksel
Kennesaw
GA, US
Agent
Nixon & Vanderhye P C
Assignee
CryoLife
GA, US
IPC
C08G 18/84
C08J 9/06
C08L 89/00
A61K 47/42
A61K 9/12
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