Processing of loop-back information returned by one or more mobile stations that are served by a wireless communication network permits the network to compensate its transmit signals for increased transmission efficiency and reduced signal interference at the mobile stations. Generally, the network forms one or more transmit signals as a combination of different signals intended for the different mobile stations, and remembers transmit information associated with these transmit signals. The mobile stations return loop-back signals to the network, which determines transmit signal compensation information by comparing loop-back information to memorized information. The mobile stations may loop-back samples from composite received signals, from processed received signal samples, or loop-back estimates. In the first case, processing at the network involves compensating the combined transmit signals at the transmit modulation rate, while the second case involves symbol rate processing of the individual information streams intended for the different mobile stations.