07194063 is referenced by 109 patents and cites 16 patents.

A method of performing radiation therapy includes delivering a therapeutic dose such as X-ray only to a target (e.g., tumor) with continuous broad beam (or in-effect continuous) using arrays of parallel planes of radiation (microbeams/microplanar beams). Microbeams spare normal tissues, and when interlaced at a tumor, form a broad-beam for tumor ablation. Bidirectional interlaced microbeam radiation therapy (BIMRT) uses two orthogonal arrays with inter-beam spacing equal to beam thickness. Multidirectional interlaced MRT (MIMRT) includes irradiations of arrays from several angles, which interleave at the target. Contrast agents, such as tungsten and gold, are administered to preferentially increase the target dose relative to the dose in normal tissue. Lighter elements, such as iodine and gadolinium, are used as scattering agents in conjunction with non-interleaving geometries of array(s) (e.g., unidirectional or cross-fired (intersecting) to generate a broad beam effect only within the target by preferentially increasing the valley dose within the tumor.

Title
Methods for implementing microbeam radiation therapy
Application Number
11/54001
Publication Number
7194063 (B2)
Application Date
February 10, 2005
Publication Date
March 20, 2007
Inventor
James F Hainfeld
Shoreham
NY, US
Gerard M Morris
Oxford
GB
F Avraham Dilmanian
Yaphank
NY, US
Agent
Lori Anne Neiger
Assignee
Brookhaven Science Associates
NY, US
IPC
A61N 5/10
View Original Source