07192450 is referenced by 647 patents and cites 325 patents.

A membrane for implantation in soft tissue comprising a first domain that supports tissue ingrowth, disrupts contractile forces typically found in a foreign body response, encourages vascularity, and interferes with barrier cell layer formation, and a second domain that is resistant to cellular attachment, is impermeable to cells and cell processes, and allows the passage of analytes. The membrane allows for long-term analyte transport in vivo and is suitable for use as a biointerface for implantable analyte sensors, cell transplantation devices, drug delivery devices, and/or electrical signal delivering or measuring devices. The membrane architecture, including cavity size, depth, and interconnectivity, provide long-term robust functionality of the membrane in vivo.

Title
Porous membranes for use with implantable devices
Application Number
10/647065
Publication Number
7192450 (B2)
Application Date
August 22, 2003
Publication Date
March 20, 2007
Inventor
Mark A Tapsak
Orangeville
PA, US
Victoria Carr Brendel
Pleasanton
CA, US
James H Brauker
San Diego
CA, US
Agent
Knobbe Martens Olson & Bear
Assignee
DexCom
CA, US
IPC
A61F 2/02
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