07190818 is referenced by 53 patents and cites 174 patents.

A method and apparatus for automated cell analysis of biological specimens automatically scans at a low magnification to acquire images (288) which are analyzed to determine candidate cell objects of interest. The low magnification images are converted from a first color space to a second color space (290). The color space converted image is then low pass filtered (292) and compared to a threshold (294) to remove artifacts and background objects from the candidate object of interest pixels of the color converted image. The candidate object of interest pixels are morphologically processed (296) to group candidate object of interest pixels together into groups which are compared to blob parameters (298) to identify candidate objects of interest which correspond to cells or other structures relevant to medical diagnosis of the biological specimen. The location coordinates of the objects of interest are stored and additional images of the candidate cell objects are acquired at high magnification. The high magnification images are analyzed in the same manner as the low magnification images to confirm the candidate objects of interest which are objects of interest. A high magnification image of each confirmed object of interest is stored for later review and evaluation by a pathologist.

Title
Method and apparatus for automated image analysis of biological specimens
Application Number
10/746515
Publication Number
7190818 (B2)
Application Date
December 24, 2003
Publication Date
March 13, 2007
Inventor
Gina McLaren
Laguna Niguel
CA, US
William J Decker
San Diego
CA, US
Bob Ellis
Laguna Niguel
CA, US
Agent
Fish & Richardson P C
Assignee
Clarient
CA, US
IPC
G06K 9/00
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