07176256 is referenced by 30 patents and cites 190 patents.

Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has been modified to contain multiple nucleophilic groups, such as primary amino (—NH2)or thiol (—SH) groups. The second synthetic polymer may be a hydrophilic or hydrophobic synthetic polymer which contains, or has been derivatized to contain, two or more electrophilic groups, such as succinimidyl groups. The compositions may further comprise other components, such as naturally occurring polysaccharides or proteins (such as glycosaminoglycans or collagen) and/or biologically active agents. Also disclosed are methods for using the crosslinked polymmer compositions to effect adhesion between a first surface and a second surface; to effect tissue augmentation; to prevent the formation of surgical adhesions; and to coat a surface of a synthetic implant.

Title
Biocompatible crosslinked composition
Application Number
10/873833
Publication Number
7176256 (B2)
Application Date
June 21, 2004
Publication Date
February 13, 2007
Inventor
Richard A Berg
Los Altos
CA, US
Frank A DeLustro
Belmont
CA, US
Woonza M Rhee
Palo Alto
CA, US
Agent
Mintz Levin Cohn Ferris Glovsky and Popeo P C
Assignee
Angiotech Pharmaceuticals
WA, US
IPC
A61K 47/48
A61K 31/785
A61K 31/74
C08L 89/00
C08G 69/48
C08G 63/91
C08G 63/02
C08F 283/00
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