07163688 is referenced by 41 patents and cites 25 patents.

An osmotic delivery system for controlled delivery of a beneficial agent includes an implantable capsule containing a beneficial agent and an osmotic engine that swells on contact with water, thereby causing the release of the beneficial agent over time. The osmotic delivery system has a membrane material that allows a controlled amount of fluid to enter from an exterior of the capsule, while preventing the compositions within the capsule from passing out of the capsule. The osmotic delivery system is designed to meet at least the operating pressures of 1000 psi. The membrane material is cast, calendered or extruded followed by machining (i.e., die-cutting, stamping or otherwise cutting to shape) to provide a uniform nonribbed membrane material. The capsule also includes a membrane material-retaining means that is positioned at a fluid uptake end to retain the membrane material within the capsule, even under periods of high pressure.

Title
Osmotic implant with membrane and membrane retention means
Application Number
10/173992
Publication Number
7163688 (B2)
Application Date
June 18, 2002
Publication Date
January 16, 2007
Inventor
James E Brown
Los Gatos
CA, US
Scott J Gilbert
Menlo Park
CA, US
John R Peery
Stanford
CA, US
Assignee
ALZA Corporation
CA, US
IPC
A61K 9/48
A61F 2/00
A61F 13/00
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