07160423 is referenced by 65 patents and cites 112 patents.

Methods and systems that employ hybrid fluid flow profiles for optimized movement of materials through channel networks. These systems employ hybrid pressure-based and electrokinetic based flow systems for moving materials through interconnected channel networks while maintaining interconnection among the various channel segments. In particular, the invention is generally directed to channel networks where flow in a first channel segment is driven by pressure flow with its consequent parabolic flow profile, while flow in an interconnected channel segment is dominated by electrokinetic flow with its consequent plug flow profile. The invention also provides channel networks wherein fluid flow in channel segments is driven by both pressure and electric field and the multiple species contained in a fluid plug are separated by altering the applied pressure and electric fields in the various channel segments of the channel networks.

Title
Mixed mode microfluidic systems
Application Number
10/386900
Publication Number
7160423 (B2)
Application Date
March 4, 2003
Publication Date
January 9, 2007
Inventor
Michael Spaid
Mountain View
CA, US
J Wallace Parce
Palo Alto
CA, US
Ring Ling Chien
San Jose
CA, US
Agent
Ann C Petersen
Donald R McKenna
Assignee
Caliper Life Sciences
CA, US
IPC
G01N 27/447
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