07157423 is referenced by 33 patents and cites 39 patents.

Fumaric acid amides of the general formula (I) wherein R1 represents OR3 or a D- or L-amino acid radical —NH—CHR4—COOH bonded via an amide bond, wherein R3 is hydrogen, a straight-chained or branched, optionally substituted C1-24 alkyl radical, a phenyl radical or C6-10 aralkyl radical and R4 is a side chain of a natural or synthetic amino acid and R2 represents a D- or L-amino acid radical —NH—CHR5—COOH bonded via an amide bond or a peptide radical comprising 2 to 100 amino acids bonded via an amide bond, wherein R5 is a side chain of a natural or synthetic amino acid, are used for preparing a drug (1) for the therapy of an autoimmune disease; (2) for use in transplantation medicine; (3) for the therapy of mitochondrial diseases; or (4) for the therapy of NF-kappaB mediated diseases.

Title
Fumaric acid amides
Application Number
10/433295
Publication Number
7157423 (B2)
Application Date
January 8, 2002
Publication Date
January 2, 2007
Inventor
Hans Peter Strebel
Lucerne
CH
Rajendra Kumar Joshi
Zürich
CH
Agent
Constance Yeung
Assignee
Fumapharm
CH
IPC
C07K 1/107
C07K 2/00
A61K 38/02
A61K 38/00
C07K 7/04
C07K 7/64
A61K 38/08
A61K 38/11
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