07147851 is referenced by 32 patents and cites 35 patents.

The present invention relates to humanized immunoglobulins having binding specificity for α4β7 integrin, comprising an antigen binding region of nonhuman origin (e.g., rodent) and at least a portion of an immunoglobulin of human origin (e.g., a human framework region, a human constant region). In one embodiment, the humanized immunoglobulin can compete with murine Act-1 for binding to human α4β7 integrin. In a preferred embodiment, the antigen binding region of the humanized immunoglobulin comprises each of the complementarity determining regions of the light and heavy chains of the murine Act-1 antibody.

Title
Humanized immunoglobulin reactive with α4β7 integrin
Application Number
8/700737
Publication Number
7147851 (B1)
Application Date
August 15, 1996
Publication Date
December 12, 2006
Inventor
Mary M Bendig
London
GB
José Saldanha
Enfield
GB
Walter Newman
Boston
MA, US
S Tarran Jones
Radlett
GB
Douglas J Ringler
Revere
MA, US
Paul D Ponath
Boston
MA, US
Agent
Hamilton Brook Smith & Reynolds P C
Assignee
Millennium Pharmaceuticals
MA, US
IPC
C07K 16/18
C07K 16/28
A61K 39/395
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