07056738 is referenced by 21 patents.

Marrow stromal cells (MSCS) are adult stem cells from bone marrow that can differentiate into multiple non-hematopoietic cell lineages. Colonies of human MSCs were shown to contain both small, rapidly self-renewing stem cells (RS cells) and large, more mature cells (mMSCs). Samples enriched for RS cells had a greater potential for multipotential differentiation than samples enriched for mMSCs. Also, RS cells have a series of surface epitopes and expressed proteins that can be used to differentiate RS cells from mMSCs. The results suggest that it will be important to distinguish the two major sub-populations of MSCs in defining their biology and their potentials for cell and gene therapy.

Title
Early stage multipotential stem cells in colonies of bone marrow stromal cells
Application Number
9/816182
Publication Number
7056738 (B2)
Application Date
March 23, 2001
Publication Date
June 6, 2006
Inventor
Ichiro Sekiya
New Orleans
LA, US
David C Colter
Philadelphia
PA, US
Darwin J Prockop
New Orleans
LA, US
Agent
Drinker Biddle & Reath
Assignee
Philadelphia Heath and Education Corporation
PA, US
Tulane University
LA, US
IPC
C12N 5/02
C12N 5/00
C12N 5/08
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