07049306 is referenced by 33 patents and cites 71 patents.

Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.

Title
Heteroaryl, heterocyclic and aryl compounds which inhibit leukocyte adhesion mediated by VLA-4.
Application Number
10/251442
Publication Number
7049306 (B2)
Application Date
September 20, 2002
Publication Date
May 23, 2006
Inventor
Ying Zi Xu
Fremont
CA, US
Christopher Semko
Fremont
CA, US
Francine S Grant
Milpitas
CA, US
Darren B Dressen
San Mateo
CA, US
Eugene D Thorsett
Half Moon Bay
CA, US
Michael A Pleiss
Sunnyvale
CA, US
Andrei W Konradi
San Francisco
CA, US
Agent
Foley & Lardner
Assignee
Elan Pharmaceuticals
CA, US
IPC
C07D 242/02
C07D 241/00
A61K 31/4985
A61K 31/313
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