07018619 is referenced by 70 patents and cites 176 patents.

The present invention relates to the delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route. Specifically, it relates to aerosols containing alprazolam, estazolam, midazolam or triazolam that are used in inhalation therapy. In a method aspect of the present invention, alprazolam, estazolam, midazolam or triazolam is administered to a patient through an inhalation route. The method comprises: a) heating a composition of alprazolam, estazolam, midazolam or triazolam, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles with less than 5% drug degradation products. In a kit aspect of the present invention, a kit for delivering alprazolam, estazolam, midazolam or triazolam through an inhalation route is provided which comprises: a) a thin coating of an alprazolam, estazolam, midazolam, or triazolam composition and b) a device for dispensing said thin coating as a condensation aerosol.

Title
Delivery of alprazolam, estazolam midazolam or triazolam through an inhalation route
Application Number
10/735495
Publication Number
7018619 (B2)
Application Date
December 12, 2003
Publication Date
March 28, 2006
Inventor
Alejandro C Zaffaroni
Atherton
CA, US
Joshua D Rabinowitz
Mountain View
CA, US
Agent
William L Leschensky
Swanson & Bratschun
Assignee
Alexza Pharmaceuticals
CA, US
IPC
A61K 15/00
A61K 9/14
A61K 9/12
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