07001378 is referenced by 116 patents and cites 453 patents.

An enhanced method and device are provided to treat atrial fibrillation or inhibit or reduce restenosis following angioplasty or stent placement. A balloon-tipped catheter is disposed in the area treated or opened through balloon angioplasty immediately following angioplasty. The balloon, which can have a dual balloon structure, may be delivered through a guiding catheter and over a guidewire already in place. A fluid such as a perfluorocarbon flows into the balloon to freeze the tissue adjacent the balloon, this cooling being associated with reduction of restenosis. A similar catheter may be used to reduce atrial fibrillation by inserting and inflating the balloon such that an exterior surface of the balloon contacts at least a partial circumference of the portion of the pulmonary vein adjacent the left atrium. In another embodiment, blood perfusion is performed simultaneously. In another embodiment, tissue contacted by the cryoablation catheter, undesired to be ablated, is protected against damage by a separate heating step.

Title
Method and device for performing cooling or cryo-therapies, for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection
Application Number
10/110360
Publication Number
7001378 (B2)
Application Date
March 1, 2002
Publication Date
February 21, 2006
Inventor
Rebecca S Inderbitzen
San Diego
CA, US
Stephen R Cooper
Carlsbad
CA, US
Hans W Kramer
Temecula
CA, US
John D Dobak III
La Jolla
CA, US
Steven A Yon
San Diego
CA, US
Agent
Karin E Williams Esq
Mark D Wieczorek Esq
Mayer Fortkort & Williams PC
Assignee
Innercool Therapies
CA, US
IPC
A61B 18/18
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