06994706 is referenced by 139 patents and cites 12 patents.

An apparatus and a method for treatment of benign prostatic hyperplasia are disclosed. The apparatus includes an applicator piece carrying a set of electrodes shaped and positioned to create a substantial electric field in the volume of hyperplasia and a pulse generator adapted for delivery of electrical pulses above the upper electroporation limit for the neoplastic cells. The amplitude, duration and number of the electrical pulses are generally selected to cause necrosis of a significant fraction of the volume of benign prostatic hyperplasia. The apparatus may include a high frequency system for heating the prostatic tissue and a cooling system for cooling the urethra. The combined action of heating and cooling may increase the temperature of the prostate cells to 45° C. to 55° C., while keeping the urinary tract at a temperature 15° C. to 20° C. This temperature distribution can increase the selectivity of the treatment by increasing susceptibility of the neoplastic cells to the electroporation treatment and decreasing it for the normal urethral tissues.

Title
Apparatus and method for treatment of benign prostatic hyperplasia
Application Number
10/217749
Publication Number
6994706 (B2)
Application Date
August 13, 2002
Publication Date
February 7, 2006
Inventor
Ali Jaafar
Eden Prairie
MN, US
Victor Chornenky
Minnetonka
MN, US
Agent
Craig Gregersen
Assignee
Minnesota Medical Physics
MN, US
IPC
A61B 18/18
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