06943199 is referenced by 18 patents and cites 22 patents.

Substituted spiro[isobenzofuran-1,4′-piperidin]-3-ones and 3H-spiroisobenzofuran-1,4′-piperidines capable of modulating NPY5 receptor activity are provided. Such compounds may be used to modulate ligand binding to NPY5 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of disorders (e.g., eating disorders such as obesity or bulimia, psychiatric disorders, diabetes and cardiovascular disorders such as hypertension) in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such compounds for detecting NPY5 receptors.

Title
Spiro[isobenzofuran-1,4′-piperidin]-3-ones and 3H-spiroisobenzofuran-1,4′-piperidines
Application Number
10/410648
Publication Number
6943199 (B2)
Application Date
April 9, 2003
Publication Date
September 13, 2005
Inventor
Xiaozhang Zheng
Branford
CT, US
Alan Hutchison
Madison
CT, US
Stéphane De Lombaert
Madison
CT, US
Agent
Sonia K Guterman
Lawson & Weitzen
Assignee
Neurogen Corporation
CA, US
IPC
C07D 401/04
C07D 471/22
C07D 471/10
A61K 003/438
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