06920357 is referenced by 166 patents and cites 13 patents.

The present invention uses electrical stimulation of the vagus nerve to treat epilepsy with minimized or no effect on the heart. Treatment is carried out by an implantable signal generator, one or more implantable electrodes for electrically stimulating a predetermined stimulation site of the vagus nerve, and a sensor for sensing characteristics of the heart such as heart rate. The heart rate information from the sensor can be used to determine whether the vagus nerve stimulation is adversely affecting the heart. Once threshold parameters are met, the vagus nerve stimulation may be stopped or adjusted. In an alternative embodiment, the invention may include a modified pacemaker to maintain the heart in desired conditions during the vagus nerve stimulation. In yet another embodiment, the invention may be simply a modified pacemaker having circuitry that determines whether a vagus nerve is being stimulated. In the event that the vagus nerve is being stimulated, the modified pacemaker may control the heart to maintain it within desired conditions during the vagus nerve stimulation.

Vagal nerve stimulation techniques for treatment of epileptic seizures
Application Number
Publication Number
6920357 (B2)
Application Date
May 12, 2003
Publication Date
July 19, 2005
Mark G Frei
Lawrence, 66047
Ivan Osorio
Leawood, 66209
Donald R Schoonover
A61N 001/18
View Original Source