06918927 is referenced by 221 patents and cites 26 patents.

A medical device (10) includes a structure (12) adapted for introduction into a patient, the structure (12) being formed of a preferably non-porous base material (14) having a roughened or textured surface (16). The structure (12) is conveniently configured as a vascular stent with a base material (14) of stainless steel, nitinol or another suitable material. The medical device (10) also includes a layer (18) of a bioactive material posited directly upon the roughened or textured surface (16) of the base material (14) of the structure (12). The surface (16) of the base material (14) is roughened or textured by etching or by abrasion with sodium bicarbonate or another suitable grit. A preferred roughened or textured surface (16) is thought to have a mean surface roughness of about 10 μin. (about 250 nm) and a surface roughness range between about 1 μin. and about 100 μin. (about 25 nm and about 2.5 μm). The particularly preferred use of sodium bicarbonate as the abrasive to provide roughness or texture to the surface (16) of the base material (14) of the structure (12) is additionally advantageous in the low toxicity of the sodium bicarbonate to production workers, the ease of product and waste cleanup, and the biocompatibility of any residual sodium bicarbonate.

Title
Coated implantable medical device
Application Number
10/659
Publication Number
6918927 (B2)
Application Date
October 31, 2001
Publication Date
July 19, 2005
Inventor
Neal E Fearnot
West Lafayette
IN, US
James D Purdy
Lafayette
IN, US
Brian D Choules
Brookston
IN, US
William J Bourdeau
Lafayette
IN, US
Joseph M Stewart IV
Delphi
IN, US
Anthony O Ragheb
West Lafayette
IN, US
Brian L Bates
Bloomington
IN, US
Agent
Richard J Godlewski
Assignee
MED Institute
IN, US
Cook Incorporated
IN, US
IPC
A61L 027/00
A61F 002/02
A61F 002/06
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