An image sensing device, such as a CMOS Active Pixel Sensor (APS) device, includes an array of pixels. Each pixel includes a reset transistor connected between a photodetector and a supply voltage. In a readout operation, a signal integrated onto the photodetector is sampled onto a holding capacitor. The photodetector is then reset in a reference reset operation during which the photodetector is clamped to the supply voltage. A reset signal is sampled from the pixel while the photodetector is clamped to the supply voltage. Reset, or kTC, noise in the reset signal may be filtered by a source-follower transistor in the pixel.