06911424 is referenced by 73 patents and cites 45 patents.

A class of 2′-fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formulae: wherein Base is a purine or pyrimidine base; R1 is OH, H, OR3, N3, CN, halogen, including F, or CF3, lower alkyl, amino, loweralkylamino, di(lower)alkylamino, or alkoxy, and base refers to a purine or pyrimidine base; R2 is H, phosphate, including monophosphate, diphosphate, triphosphate, or a stabilized phosphate prodrug; acyl, or other pharmaceutically acceptable leaving group which when administered in vivo, is capable of providing a compound wherein R2 is H or phosphate; sulfonate ester including alkyl or arylalkyl sulfonyl including methanesulfonyl, benzyl, wherein the phenyl group is optionally substituted with one or more substituents as described in the definition of aryl given above, a lipid, an amino acid, peptide, or cholesterol; and R3 is acyl, alkyl, phosphate, or other pharmaceutically acceptable leaving group which when administered in vivo, is capable of being cleaved to the parent compound, or a pharmaceutically acceptable salt thereof.

Title
2′-fluoronucleosides
Application Number
10/61128
Publication Number
6911424 (B2)
Application Date
January 30, 2002
Publication Date
June 28, 2005
Inventor
Joon H Hong
Athens
GA, US
Kyeong Lee
Athens
GA, US
Yongseok Choi
Athens
GA, US
Junxing Shi
Decatur
GA, US
J Jeffrey McAtee
Atlanta
GA, US
Chung K Chu
Athens
GA, US
Dennis C Liotta
McDonough
GA, US
Raymond F Schinazi
Decatur
GA, US
Agent
King & Spalding
Sherry M Knowles Esq
Assignee
Emory University
GA, US
IPC
C07H 019/00
C07H 011/00
C07H 001/00
A01N 043/04
A01N 061/00
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