06902743 is referenced by 89 patents and cites 47 patents.

Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer having a molar composition of lactide/glycolide from 90/10 to 40/60, which may contain a pharmaceutically-acceptable adjuvant, as a blend of uncapped free carboxyl end group and end-capped forms ranging to ratios from 100/0 to 1/99.

Title
Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix
Application Number
9/55505
Publication Number
6902743 (B1)
Application Date
April 6, 1998
Publication Date
June 7, 2005
Inventor
Wendell Zollinger
Silver Spring
MD, US
Jerald Sadoff
Washington
DC, US
Alan Cross
Chevy Chase
MD, US
Apurba Bhattacharjee
Kensington
MD, US
Charles E McQueen
Olney
MD, US
F Donald Roberts
Dover
MA, US
Phil Friden
Bedford
MA, US
Ramassubbu Jeyanthi
Columbia
MD, US
Edgar C Boedecker
Crownsville
MD, US
John van Hamont
West Point
NY, US
Robert H Reid
Kensington
MD, US
Elliot Jacob
Silver Spring
MD, US
Thomas R Tice
Birmingham
AL, US
Jean A Setterstrom
Alpharetta
GA, US
Agent
Charles H Harris
John Francis Moran
Elizabeth Arwine
Assignee
The United States of America represented by the Secretary of the Army
DC, US
IPC
A61K 009/16
A61K 009/26
A61K 009/48
A61K 039/40
A61K 009/14
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