06896659 is referenced by 41 patents and cites 21 patents.

A method is provided for site specific delivering therapeutic or diagnostic agents to a region in a fluid-filled cavity, vessel or tissue using an agent-loaded microbubble population. The population has controlled fragility characterized by a uniform wall thickness to diameter ratio which defines the discrete threshold intensity value of ultrasonic power where microbubble rupture occurs in the population. The location of the microbubble population may be monitored by ultrasound to determine its presence at the region prior to application of the ultrasonic power to rupture to microbubbles.

Title
Method for ultrasound triggered drug delivery using hollow microbubbles with controlled fragility
Application Number
10/28738
Publication Number
6896659 (B2)
Application Date
October 22, 2001
Publication Date
May 24, 2005
Inventor
E Glenn Tickner
Watsonville
CA, US
Thomas B Ottoboni
Belmont
CA, US
Ronald Yamamoto
San Francisco
CA, US
Stanley R Conston
San Carlos
CA, US
Agent
Dechert
Ann M Caviani Pease
Assignee
Point Biomedical Corporation
CA, US
IPC
A61B 008/14
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