06887270 is referenced by 191 patents and cites 71 patents.

Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents.

Title
Implantable or insertable medical device resistant to microbial growth and biofilm formation
Application Number
10/71840
Publication Number
6887270 (B2)
Application Date
February 8, 2002
Publication Date
May 3, 2005
Inventor
Ronald A Sahatjian
Lexington
MA, US
Peter L Dayton
Brookline
MA, US
Kurt Geitz
Sudbury
MA, US
Gregory T Sydney
Sharon
MA, US
Kathleen M Miller
Shrewsbury
MA, US
Agent
David B Bonham Esq
Mayer Fortkort & Williams PC
Assignee
Boston Scientific SciMed
MN, US
IPC
A61L 031/16
A61F 002/00
C08K 003/00
A61L 027/00
A61M 025/00
A61L 031/10
A61L 029/00
A61L 029/00
C08K 005/00
A61F 025/00
A61F 002/02
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