06881551 is referenced by 790 patents and cites 307 patents.

A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible.

Title
Subcutaneous glucose electrode
Application Number
10/353341
Publication Number
6881551 (B2)
Application Date
January 28, 2003
Publication Date
April 19, 2005
Inventor
Michael V Pishko
Austin
TX, US
Adam Heller
Austin
TX, US
Agent
Merchant & Gould P C
Assignee
TheraSense
CA, US
IPC
C12M 001/00
C12Q 001/28
C12Q 001/26
C12Q 001/00
C12Q 001/54
View Original Source