A system providing methods for anti-virus cooperative enforcement is described. In response to a request from a device for access to protected resources, such as a network or protected data, a determination is made as to whether an anti-virus policy applies to the request for access made by the device. If an anti-virus policy is applicable, information pertaining to virus protection available on the device is collected. The virus protection information that is collected is evaluated to determine whether the device is in compliance with the anti-virus policy. If the device is determined to be in compliance with the anti-virus policy, the device is allowed to access the protected resources.