06861053 is referenced by 58 patents and cites 52 patents.

Disclosed is a method of diagnosing irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, depression, attention deficit/hyperactivity disorder, autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus, or Crohn's disease, which involves detecting the presence of small intestinal bacterial overgrowth (SIBO) in a human subject having at least one symptom associated with a suspected diagnosis of any of those diagnostic categories. Also disclosed is a method of treating these disorders, and other disorders caused by SIBO, that involves at least partially eradicating a SIBO condition in the human subject. The method includes administration of anti-microbial or probiotic agents, or normalizing intestinal motility by employing a prokinetic agent. The method improves symptoms, including hyperalgesia related to SIBO and disorders caused by SIBO. Also disclosed is a kit for the diagnosis or treatment of irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, depression, attention deficit/hyperactivity disorder, autoimmune diseases, or Crohn's disease.

Title
Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
Application Number
9/374142
Publication Number
6861053 (B1)
Application Date
August 11, 1999
Publication Date
March 1, 2005
Inventor
Mark Pimentel
Los Angeles
CA, US
Henry C Lin
Manhattan Beach
CA, US
Agent
Pillsbury Winthrop
Assignee
Cedars Sinai Medical Center
CA, US
IPC
A61K 039/00
A61K 035/00
A01N 037/18
A01N 065/00
A01N 063/00
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